Amir Sotoudeh, Gholam Reza Abedi, Masoud Soleimani , Mohammad Reza Aflatoonian, Amirali Jahanshahi, Mohammad Ashrafzadeh
Nanofiber, tissue engineering, scaffold, electrospining,repair
In tissue engineering, biodegradable scaffold is designed to protect newly formed tissue in its early stages. This study evaluates the potential of electrospun collagen PVA biodegradable nanofiber scaffold to cartilage tissue engineering. Nanofiber scaffolds were fabricated by electrospining. A full thickness defect of diameter 4 mm and depth 3 mm on the articular cartilage was made in both stifle joint of 10 rabbits. In Group 1 the collagen- PVA scaffold was implanted into the right stifle and in the left stifle, the defect was left without any treatment as the control group (Group II). Speciment were harvested at 12 weeks after implantation; regenerated tissues were evaluated grossly and histologically. The Hylin repair was more obvious in Group I which filled with white translucent cartilage tissue which appeared tenacious and ill-demarcate from the surrounding normal cartilage. But the surface integration of the newly formed cartilage plug with host cartilage was not very well. The percentage of Hyaline-appearing cartilage in Group I was better than control group. This study showed better results of articular cartilage reconstruction by means of a biodegradable scaffolds. It also renders these devices excellent vehicles for chondrocyte or stem cell transplantation. .
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