Saleh Ramezani, Wu Chen, and Alan W.L. Chiu
Oscillator model, complexity analysis, receptor dynamics, NMDA,AMPA, GABA
The hippocampus plays a crucial role in information storage and is associated with long-term episodic and semantic memories. It is frequently used as a test bed for the development and evalu- ation of neural prosthetic devices for cognitive function restoration. Here, a modification of the mapped clock oscillator (MCO) model representation of the hippocampal CA3 region was developed. We addressed several limitations with the experimental design of the existing MCO model. It was modified to include kinetics of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) and γ-aminobutyric acid (GABAA) receptors, capable of generating activity in close agreement with experimental results. The model response showed that lower than normal magnesium concentrations will increase the network excitability in the absence of AMPA and GABAA receptors. In a network of reciprocally connected MCOs, effective synaptic excitation will increase the excitability of the network, while effective synaptic inhibition would push the network towards less excitable states. The new glutamatergic and GABAergic receptor pathways were also designed to be adaptive, making them more suitable for the future integration with a hippocampal system for cognitive neural prosthesis.
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