Alginate and Gelatine Blending for Bone Cell Printing and Biofabrication

Rainer Detsch, Bapi Sarker, Alexandra Grigore, and Aldo R. Boccaccini


Alginate-gelatine , Soft matrices, Cell printing, Biofabrication


In order to develop suitable materials for biofabrication, the current work focused on the fabrication and characterization of alginate-gelatine matrices. Alginate-gelatine blends were prepared by mixing the stock solutions of alginate and gelatine in different ratios: 80/20 and 60/40. Films of these materials were chemical and mechanical characterised. To evaluate the cell behaviour of the different soft matrices, MG-63 osteoblast-like cells were employed. As a consequence, all investigated alginate matrices are suitable for cell encapsulation or rapid prototyping, promoting high cell viability. However, the most promising material is alginate blended with gelatin due to the extensive cell-matrix interactions and cell ability to migrate and proliferate through the hydrogel.

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