Four Phenotype Model of Interaction between Tumour Cells

Andrzej Swierniak, Michal Krzeslak, and Jaroslaw Smieja


Biomathematical modeling, Bioinformatics, Evolutionary games, Cancer


Evolutionary game theory applications are widely used to simulation of tumor processes. Inter-cellular interactions that occur among tumor population are good examples of biological evolutionary games for site and recourses. Presented extended model considers four strategies (phenotypes) that can arise by mutations: cells that produce harming substances to gain advantage, cells resistant to these substances, cells that produce growth factor which affects any other cell-kinds and neutral cells. Different equilibrium points, scenarios and possible extensions are also discussed.

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