R. Kumar, S. Ngai, M. Bardsley, N. Panoskaltsis, F. Stepanek, and A. Mantalaris (UK)
Oxygen Transport, Human Bone Marrow, Sickle Cell Disease, and CFD.
There has been a relative paucity in the understanding of the in vivo bone marrow (BM) pathophysiology under sickle cell disease (SCD); especially in the human BM. In this study, a model that accounts for oxygen transport for sickle cell red blood cells (RBC) within an idealized heterogeneous structure of the human BM has been developed. This has been achieved by combining the well developed mathematical model for haemoglobin solutions in large microcirculatory vessels with the transport and the haemoglobin polymerisation model developed by Makhijani et al., 1990, and the oxygen transport model for human BM by Kumar et.al., 2004. The resulting set of equations allows us to simultaneously simulate the important processes of oxygen delivery with polymerisation and its effect on the various cellular distributions within the BM under SCD. The model is solved using the commercial CFD software CFX 4.4 (CFX-ANSYS ). The development of such physiologically relevant models will enable further understanding of the BM under normal and pathological conditions.
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