Solid Lipid Nanoparticles as Sunscreen Carrier System and its Toxicity in Zebrafish Embryos

P.D. Marcato, L.F. Adami, J. Caverzan, S.C. Huber (Brazil), T. Misset, J. den Hertog, C.V. Ferreira (The Netherlands), and N. Durn (Brazil)


Solid lipid nanoparticles, sunscreens, toxicity, Zebrafish embryos.


The interest in developing the new sunscreens is been increasing in the last years due to the harmful effects of UV radiation on the skin such as erythema, accelerated skin ageing (photoageing) and the induction of skin cancer. In this way, nanostructures have being used in sunscreen formulation. Submicron emulsions, nanospheres, nanocapsules, liposomes and solid lipid nanoparticles are some of the nanostructures applied in sunscreen. The aim of this work was preparation and characterization of the solid lipid nanoparticles as carrier of the benzophenone-3 (sunscreen) with the main goals to reduce the penetration of this sunscreen into the skin and its effective concentration.The benzophenone-3 was encapsulated in solid lipid nanoparticles by hot high pressure homogenization method. The particles were characterized in terms of morphology, encapsulation efficiency and in vivo toxicity by Zebrafish embryos as a model.

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