A New Approach to Protect Proteins in 2D Gel Electrophoresis Images

J. Chen, T.-S. Chen, and J.-Y. Pan (Taiwan)


Data encryption standard (DES), Protein spots, two dimensional gel electrophoresis (2DGE), detect, modifications


2D gel electrophoresis (2DGE) is popularly used by biologists to analyze protein characteristics in order to diagnose the state of health of a patient. Therefore protecting the 2DGE images against illegal modifications and maintaining the integrity of these images are very important to make an accurate diagnosis for a patient. In this paper, the important protein information on a 2DGE image will be extracted using Z3 and protected by encrypting with a key using DES. Three copies of the encrypted data were then hidden in the background region; a region that has no protein spots and, therefore, deemed unimportant. The hidden data could be extracted later on to detect for possible changes in the 2DGE image. Experimental results showed that the proposed method is easy to implement and can be used to detect for possible changes in 2DGE images and to recover from these changes.

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