J. Wu, Y. Sun, L.P. Collis, and R.B. Hill (USA)
Voltage clamp, digital signal processor, digital control, proportion-integral-derivative, neuroscience
The voltage clamp was invented in 1949 and has been an important method for studying excitable tissues ever since. The conventional voltage clamp is implemented by use of analog circuits. A digital voltage clamp system would have the advantages of flexibility in the feedback control algorithms and capability of changing clamping modes dynamically. This paper describes the development of a digital voltage clamp using a digital signal processor in the feedback loop. Modeling and simulation of the neuron and voltage clamp was an important part of the instrument development. The resulting digital voltage clamp was tested with the ventricular trabeculae of the surf clam.
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