Analyzing Gene Expression Profiles with ICA

D. Lutter, K. Stadlthanner, F. Theis, E.W. Lang (Germany), A.M. Tomé (Portugal), B. Becker, and Th. Vogt (Germany)


Independent component analysis, microarrays, gene ex pression profiles, FastICA, JADE


High-throughputgenome-wide measurements of gene tran script levels have become available with the recent devel opment of microarray technology. Intelligent and efficient mathematical and computational analysis tools are needed to read and interpret the information content buried in those large scale gene expression patterns at various levels of resolution. But the development of such methods is still in its infancy. Modern machine learning and data mining techniques based on information theory, like independent component analysis (ICA), consider gene expression pat terns as a superposition of independent expression modes which are considered putative independent biological pro cesses. We focus on two widely used ICA algorithms to blindly decompose gene expression profiles into indepen dent component profiles representing underlying biological processes. These exploratory methods will be capable of detecting similarity, locally or globally, in gene expression patterns and help to group genes into functional categories - for example, genes that are expressed to a greater or lesser extent in response to a drug or an existing disease.

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