R. Karba, A. Belič, I. Grabnar, V. Logar, A. Mrhar, and D. Matko (Slovenia)
Biomedical modelling, therapy design, urinary bladder, pharmacokinetic-pharmacodynamic studies, intravesical instillation.
Optimal drug therapies design for urinary bladder infections or even cancer is very actual on one and at the same time problematic on the other side. Urinary bladder namely represents a specific pharmacokinetic compartment due to its changeable volume. The latter varies in accordance with urine formation as well as because of micturitions which occur randomly. In the work modular model is proposed which is represented as a kind of situation diagram. However, it consists of modules which are very different in their character including volume formation and micturition (urodynamic) module, distributed parameter model of drug diffusion in the bladder wall, drug pharmacokientic model (oral,intravenous or intravesical instillation route of administration) and some possible special modules. The model might be evaluated through the curve fetting procedure using parallel genetic algorithm and mesured data. The approach is illustrated by the aid of real drug formulation study. It came out that the modularity of the model enables a variety of studies where only the modules which are important from the modelling aims point of view can be taken into account thus representing a kernel for multifaceted modelling of different aspects of urinary bladder therapies. However, also some extensions are still possible which are now under investigation.
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