Comparison of Phase-specific Chemotherapy Models WITH and WITHOUT Taking into Account Drug Resistance

J. Smieja and A. Swierniak (Poland)


Biomedical modelling, drug resistance, phase-specificchemotherapy.


This paper is concerned with phase-specific chemotherapy design. It deals with two models of the problem. The first one can be found in literature and does not take into account increasing drug resistance which is a phenomena observed in clinical research. The second model combines phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. The basic biological background for the models is given and afterwards the mathematical problem of finding optimal solution is stated. The results are subsequently presented and discussed.

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