Electroneurograms Recorded from the Left Vagus Nerve of a Dog

J. Rozman and B. Četina (Slovenia)

Keywords

Biosensors and transducers, vagus nerve, electroneurogram.

Abstract

Electroneurograms (ENGs) from superficial regions of the left vagus nerve of a dog were recorded selectively with a 39-electrode spiral cuff (cuff) implanted at the neck in Beagle dogs. By delivering stimuli on groups of three electrodes (GTEs), the relative positions of the regions that innervated the heart, respiratory muscles, stomach and urinary bladder were defined. When delivered to the GTE9, the heart rate and the mean arterial pressure (MAP) began to fall; when delivered to the GTE4, the rhythm of breathing began to fall; when delivered to the GTE7, a fall of pH within the stomach was obtained, and when delivered to the GTE4, the pressure in the bladder began to fall. The thus defined GTEs were relevant for the selective recording of ENGs from aforementioned organs. To alter a function of the heart, the carotid artery at the carotid sinus of the neck was compressed and epinephrine was intravenously injected. To alter a function of the lungs non-invasive positive pressure ventilation was used. Raw ENGs analyzed in terms of frequency spectra shown that the power spectrum of the ENG recorded with GTE9, contained frequencies corresponding to activity elicited by compression of the carotid artery and injection of the epinephrine. Furthermore, the power spectrum of the ENG recorded with GTE4, contained frequencies corresponding to activity elicited by non-invasive positive pressure ventilation.

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