Robust Pre-Processing and Noise Reduction in Microarray Images

A. Mastrogianni, E. Dermatas, and A. Bezerianos (Greece)

Keywords

automatic gridding, image denoising, wavelets.

Abstract

In this paper, a microarray image enhancement of cDNA microarray images using a novel two-level denoising technique and automatic addressing is presented. This study shows that robust denoising, based on wavelet decomposition and spot detection, can be used successfully to remove the noise from microarray images. In addition, this paper introduces a fully automatic gridding method which permits a high throughput analysis, taking into account the subarray alignment problem. The method has been found to effectively detect the grids on microarrays images, containing 99 subarrays of gene expression profiles of all types of human lymphoid malignancies.

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